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Brand name: metformin
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Use of metformin and rosiglitazone can increase the risk of serious side effects in these patients. Published clinical information exists for the use of other sulfonylureas including glyburide, glipizide, chlorpropamide, and tolbutamide in combination with metformin. After initiation of rosiglitazone maleate/metformin hydrochloride, and after dose increases, observe patients carefully for signs and symptoms of heart failure (including excessive, rapid weight gain, dyspnea, and/or edema). The active comparator metformin (n=137) was administered at 500 mg twice daily initially and titrated up to 1000 mg twice daily (mean last dose 1365 mg). Using any of them together with metformin and rosiglitazone may increase your risk of having serious side effects. , x-rays, CT scans, and MRIs) that use intravenous contrast media—Use of metformin and rosiglitazone should be discontinued before you have one of these procedures.
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